Stephen H Tsang, MD PHD

Ophthalmology

Stephen H Tsang, MD PHD

Ophthalmology

Specialties: OphthalmologyMore specialties

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635 West 165th Street
New York, NY 10032
US

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About Stephen H Tsang, MD PHD


Stephen H. Tsang, M.D, Ph.D. is an acclaimed clinical geneticist in the care of individuals with retinal degenerations. He has been culturing stem cells since 1992 and created the first mouse model for a recessive form of retinitis pigmentosa (RP) by applying genome engineering to stem cell technology in 1995. He successfully treated preclinical models of Pde6a, Pde6b, Mfrp, Rho, Cngb1 and autosomal recessive bestrophin retinopathies.


He has expertise in designing and testing genome engineering strategies in pre-clinical models, developing patient-specific knock-in models, generating of patient cell lines and providing care to patients with a precision medicine approach. He is also leading efforts in FDA trials for gene therapies, including PDE6A, RAB geranylgeranyl transferase, RPGR, CNGB3, CNGA3 and ABCA4 retinopathies.


He wrote 3 books: "Precision Medicine, CRISPR, and Genome Engineering: Moving from Association to Biology and Therapeutics; and "Stem Cell Biology and Regenerative Medicine in Ophthalmology", Springer Press, NY; and "CRISPR Genome Surgery in Stem Cells and Disease Tissues", Elsevier Inc. He is an elected member of several honorary societies including the American Society for Clinical Investigation, Alcon Research Institute and American Ophthalmological Society. He is consistently named to various NIH study sections (DPVS standing member 2014-8 and PED2 2022-6) and other review committees: Alcon Research Institute Grant Review Committee (2022-27); Scientific Advisory Panel - Research to Prevent Blindness (RPB, 2019-29), Chair of American Ophthalmological Society Thesis Review Committee (2022-2023). Many of his publications are in widely-read general interest journals such as Science, NEJM, Lancet, Cell Stem Cell, Nature Genetics, and Journal of Clinical Investigation, which attests to the broad impact that his work has had.


Dr. Tsang received a resident teaching award in 2008 and was the Columbia Ophthalmology Basic Science Course Director (2006-2018).


Dr. Tsang graduated from Johns Hopkins University, where he began his medical genetics training under the tutelage of Professor Victor A. McKusick. He received his M.D.-Ph.D. degrees from the NIH-National Institute of General Medical Sciences Medical Scientist Training Program (MSTP) at Columbia University. Dr. Tsang then completed his residency at Jules Stein Eye Institute/UCLA, followed by studies with Professors Alan C. Bird and Graham E. Holder on improving the care of individuals with macular degenerations.


Board Certifications

  • Ophthalmology

Languages Spoken

  • Cantonese

Expertise

  • Adult Genetics
  • Applied Eye Genetics
  • Clinical Genetics
  • Clinical Molecular Genetics
  • Diabetic Retinopathy
  • Electrophysiology
  • Eye Genetics
  • Genetic Disorder
  • Genetic Disorders
  • Genetic Testing
  • Hereditary Retinal Degeneration
  • Macular Degeneration
  • Marfan's Syndrome
  • Molecular Biology
  • Molecular Medicine
  • Pediatric Genetics
  • Precision Medicine
  • Retina Degeneration
  • Retina Disorder
  • Retinal Bleeding
  • Retinal Disease
  • Retinal Disorders
  • Retinal Vascular Disorders
  • Retinitis pigmentosa
  • Retinopathy
  • Skin Pigmentation Disorder
  • Stem Cell Transplantation
  • Vitreoretinal Disorder

Education

  • Medical School: Columbia University College of Physicians and Surgeons
  • Internship: New York Hospital Queens
  • Residency: UCLA - Jules Stein Eye Institute
  • Fellowship: Moorfields Eye Hospital, London

Titles & Positions

  • Course co-director, BMENE6510 Stem Cells, Genome Engineering and Regenerative Medicine
  • Laszlo T. Bito Professor of Ophthalmology, and Pathology and Cell Biology

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Awards & Honors

  • 1988 1989 Alpha Epsilon Delta, National Premedical Honor Society, Maryland Alpha (Historian)
  • 1988 1989 Deans List, The Johns Hopkins University
  • 1989 1997 NIH-National Institute of General Medical Sciences Medical Scientist Training Program: MSTP fellowship PHS Grant #T32GM073667-14
  • 1989 Graduate with Departmental Honor
  • 1989 Recipient of Student Activities Award, The Johns Hopkins University
  • 1995 ARVO/National Eye Institute Travel Fellowship Grant for the 1995 ARVO meeting
  • 1996 Deans Award for Excellence in Research, Graduate Sch of Arts & Sciences, Columbia U. Dr. Alfred Steiner Award for Best Medical Student Research, Columbia U.
  • 1997 Best Overall Presentation at Eastern Student Research Forum sponsored by American Medical Association and the University of Miami
  • 1997 Travel Grant, European Students Conference at the CharitA in Berlin
  • 1998 Edith McKane Award in Ophthalmology, College of Physicians and Surgeons, Columbia U.
  • 1998 John Lattimer Award in Urology, College of Physicians and Surgeons, Columbia U.
  • 2000 Jules Stein Eye Institute Research Award
  • 2000 RPB-Association of University Professors in Ophthalmology (AUPO) Resident Award
  • 2001 present Fight for Sight/Grant-In-Aid Review Panel Member
  • 2003 Burroughs-Wellcome Fund Career Award in Biomedical Sciences
  • 2003 Nesburn Resident Award
  • 2003 RPB Association of University Professors in Ophthalmology Resident Award
  • 2004 Dennis W. Jahnigen Award, American Geriatrics Society
  • 2005 Becker-AUPO-RPB Award
  • 2006 ARVO/Alcon Early Career Clinician Scientist Award
  • 2006 Dr. Isaac Bekhor Lecturer, Doheny Eye Institute at University of Southern California (9/29)
  • 2007 Charles E. Culpeper Award
  • 2008 2009 Listed as one of “Americas Top Ophthalmologists” by Consumers Research Council of America http://consumersresearchcncl.org/Healthcare/Ophthalmologists/top_ophth.html
  • 2008 Teacher Recognition Award, Columbia U.
  • 2009 Elected to Macular Society
  • 2009 Patients' Choice Award for 2008
  • 2010 Keynote Speaker, GTCbio 2nd Annual Ocular Disease & Drug Discovery conferen. May 28, 2010
  • 2012 Invited Lecturer, University of Geneva
  • 2013 ARVO Foundation Carl Camras Award
  • 2013 Dr. Bradley Straastma Lecturer, Resident Graduation, UCLA
  • 2013 Dr. Paul Stringer Memorial Lectureship, McMaster University
  • 2013, 14 Elected by his peers for inclusion in Best Doctors in AmericaA
  • 2014 Foundation Fighting Blindness Visionary Award Recipient and “Banking on a Cure” Honoree
  • 2015 ARVO 2015 Annual Meeting Gene Editing Symposium Invited Lecturer in Denver, Colorado
  • 2015 Chair, Gene Editing/Rewriting the Genome Symposium American Society of Human Genetics Annual Meeting
  • 2015 Dr. Joginder Nath Lecturer, West Virginia U. School of Medicine
  • 2015 Elected to American Ophthalmological Society
  • 2015 Invited Lecturer,Deutsche Ophthalmologische Gesellschaft DOG
  • 2015 Plenary lecture, Rensselaer Center for Stem Cell Research (RCSCR) - Symposium
  • 2016 Elected to American Society for Clinical Investigation
  • 2016 Lecturer, World Science Festival, CRISPR Technologies
  • 2018 Young Investigator Award, Macular Society
  • Named Lectureships

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