Robert J Winchester, MD

Rheumatology
Specialties
Internal Medicine, Rheumatology

Locations and Appointments


CUIMC/Russ Berrie Medical Science Pavilion

1150 St. Nicholas Avenue
New York, NY 10032
US
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Insurances Accepted


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    NY Signature
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    NYP Employee Plan
    Aetna Signature Administrators
    Student Health
    EPO
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    Medicaid Managed Care
    Special Needs
    Medicare Managed Care
    Special Needs
    Great West (National)
    PPO
    Medicare Managed Care
    POS
    EPO
    HMO
    PPO
    Medicare Managed Care
    Medicaid Managed Care
    Essential Plan
    Vytra
    Medicare Managed Care
    ConnectiCare
    PPO
    HMO
    Select Care (Exchange)
    POS
    EPO
    Essential Plan
    Child/Family Health Plus
    Medicaid Managed Care
    EPO
    PPO
    HMO
    Local 32BJ
    Medicaid Managed Care
    Essential Plan
    Child/Family Health Plus
    Medicare Managed Care
    Medicaid Managed Care
    Medicare Managed Care
    Leaf (Exchange)
    Child/Family Health Plus
    Local 1199
    MagnaCare
    Traditional Medicare
    Railroad
    Multiplan
    Child/Family Health Plus
    Essential Plan
    HMO
    Medicaid Managed Care
    Quality Health Management
    Special Needs
    Columbia University Employee Plan
    Medicaid (Community Plan)
    HMO
    PPO
    Empire Plan
    POS
    Medicare Managed Care
    Compass (Exchange)
    Oxford HMO
    Oxford Liberty
    Oxford Freedom
    Medicare Managed Care
    Medicaid Managed Care
    World Trade Center Health Plan

About Robert J Winchester, MD


Dr. Winchester has had a sustained interest in human autoimmunity. His earlier studies defined the molecular importance of rheumatoid factors, other autoantibodies and immune complexes in human disease. Moreover, Dr. Winchester was involved in the early identification and tissue expression of human MHC class II molecules. As importantly, his studies of the polymorphisms of MHC molecules have provided the basis of establishing the link between MHC genotype and susceptibility to autoimmunity. For example in the late 1980's Dr. Winchester and colleagues showed that susceptibility to rheumatoid arthritis was determined by sequences in the b chain of MHC class II molecules.


This observation led to the shared MHC 'epitope' hypothesis which provides a molecular basis for susceptibility to rheumatoid arthritis associated with a region on the MHC molecule involved in both binding of the peptide and interacting with the TCR. This seminal discovery has emphasized the importance of the modern means of HLA typing which involves DNA sequencing of the MHC genes and the theoretical basis for the discovery of antigens that initiate autoimmune disease. In recent years Dr. Winchester has also focused on DNA and peptide sequence analysis of T cell receptor a and b chains in order to define the changes in the TCR repertoire associated with autoimmunity.


Email: rjw8@cumc.columbia.edu


Board Certifications

  • Internal Medicine
  • Rheumatology

Education

  • Residency: New York Hospital - Cornell Medical Center
  • Medical School: Cornell University Medical College, NY
  • Internship: New York Hospital - Cornell Medical Center

Leadership, Titles & Positions

  • Professor of Medicine
  • Professor of Pathology & Cell Biology
  • Professor of Pediatrics

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

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