Dr. Accordino graduated from The Pennsylvania State University with a bachelor of science in Pre-medicine with minors in Health Policy and Administration and Biology. She completed her medical degree at The Pennsylvania State University College of Medicine. While in medical school she was elected to Alpha Omega Alpha, the national medical honor society which recognizes high educational achievement. She completed her Internal Medicine residency at Weill Cornell Medical Center and her Medical Hematology/Oncology fellowship at Columbia University Medical Center, where she served as Chief Fellow. During that time, she was awarded a Conquer Cancer Foundation of the American Society of Clinical Oncology Young Investigator Award and Merit Award. She also served as a Postdoctoral Research Fellow in Cancer-Related Population Sciences supported by the National Cancer Institute for her work in quality improvement and health outcomes research.

Upon fellowship graduation she became an Assistant Professor of Medicine within the Division of Hematology/Oncology at Columbia University. Since her faculty appointment she has received grant funding from multiple agencies including: The American Society of Clinical Oncology, The HOPE Foundation, The Breast Cancer Research Foundation, The American Cancer Society, and the National Institutes of Health/National Cancer Institute. Dr. Accordino is currently involved in patient care, clinical research, education, and quality improvement.

Dr. Accordino's research aims to improve the quality and delivery of cancer care, and cancer survivorship. Dr. Accordino participates in clinical trials at the local, national, and international level. She also has experience leading multicenter cancer trials through the SWOG Cooperative Group. The overall goal of her research is to improve quality and outcomes within oncology.