CUIMC/Herbert Irving Pavilion
161 Fort Washington Avenue
New York, NY 10032
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Insurances Accepted
Before your appointment, please contact the doctor's office or your insurance provider to verify that your insurance is accepted. This list of insurances can change, and the insurance plans listed may not be accepted at all office locations for this provider.
- Aetna Signature Administrators
- Medicare Managed Care
- HMO
- PPO
- POS
- EPO
- NY Signature
- Student Health
- Essential Plan
- Medicaid Managed Care
- Special Needs
- PPO
- HMO
- Great West (National)
- EPO
- POS
- Special Needs
- PPO
- Medicare Managed Care
- Select Care (Exchange)
- Vytra
- EPO
- Medicare Managed Care
- HMO
- PPO
- POS
- ConnectiCare
- Essential Plan
- Medicaid Managed Care
- Medicaid Managed Care
- Child/Family Health Plus
- Essential Plan
- Individual Network (Exchange)
- PPO
- Medicare Managed Care
- HMO
- EPO
- Essential Plan
- Medicaid Managed Care
- Medicare Managed Care
- Child/Family Health Plus
- Leaf (Exchange)
- Medicaid Managed Care
- Child/Family Health Plus
- Medicare Managed Care
- Medicare Managed Care
- Local 1199
- MagnaCare
- Traditional Medicare
- Railroad
- Multiplan
- HMO
- Essential Plan
- Child/Family Health Plus
- Medicaid Managed Care
- HMO
- POS
- PPO
- Empire Plan
- Oxford Liberty
- Oxford Freedom
- Oxford HMO
- Medicare Managed Care
- Medicaid (Community Plan)
- SelectHealth
- Medicare Managed Care
- Special Needs
- Medicaid Managed Care
- Medicare Managed Care
- World Trade Center Health Plan
About Gulam A. Manji, MD, PhD
Gulam A. Manji, MD, PhD, is an Associate Professor of Medicine at Columbia University Irving Medical Center, Director of Gastrointestinal Medical Oncology, Co-Director of The Pancreas Center, and co-leader of the Precision Oncology and Systems Biology Program at the Herbert Irving Comprehensive Cancer Center. He completed residency in internal medicine at Albany Medical College and fellowship in Hematology/Oncology at New York-Presbyterian/Columbia.Dr. Manji is a physician-scientist focused on developing new therapeutic strategies for gastrointestinal malignancies, particularly pancreatic ductal adenocarcinoma. His translational research bridges tumor immune microenvironment biology, stromal signaling, KRAS/RAS pathway targeting, CXCR4-CXCL12 biology, autophagy and MAPK signaling, adenosine-mediated immunosuppression, and biomarker-driven clinical trial development.A major focus of his work has been the CXCR4-CXCL12 pathway in pancreatic cancer. Building on preclinical studies showing that CXCR4 inhibition can remodel the pancreatic tumor microenvironment and enhance antitumor immunity, Dr. Manji advanced this work from bench to bedside through an investigator-initiated clinical trial combining chemotherapy, CXCR4 inhibition, and immune checkpoint blockade. The pilot study demonstrated impressive tumor shrinkage, including one pathologic complete response among 11 patients, and was published in Nature Communications in 2026. These findings supported expansion into a multicenter randomized phase 2 trial that is currently enrolling patients.Dr. Manji has also contributed to major advances in RAS-directed therapy for pancreatic cancer. He was a co-contributor to the Nature publication evaluating RMC-7977, a RAS-GTP inhibitor tool compound, in preclinical pancreatic cancer models, helping establish the rationale for broad-spectrum RAS inhibition in pancreatic cancer. He also played a role in the positive phase 3 daraxonrasib clinical trial in previously treated metastatic pancreatic cancer, which demonstrated significant improvements in progression-free and overall survival and was published in The New England Journal of Medicine.Clinically, Dr. Manji cares for patients with pancreatic, hepatobiliary, colorectal, and upper gastrointestinal cancers. His overarching goal is to bring rational, biomarker-informed therapeutic combinations from the laboratory to the clinic to improve outcomes for patients with pancreatic and other gastrointestinal malignancies.
Recent publications: manji ga - Search Results - PubMedTo donate to the Manji Research Gift Fund: https://medicine.givenow.columbia.edu/
Board Certifications
Specialties & Expertise
EDUCATION
- Medical School: Ross University School of Medicine
- Medical School: University of Wisconsin
- Residency: Albany Medical Center
- Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
LEADERSHIP, TITLES & POSITIONS
- Assistant Professor of Medicine at CUMC
- Director of Gastrointestinal Oncology
- Director of Pancreas Translational Research
- Co-Director of The Pancreas Center
HOSPITAL AFFILIATIONS
- NewYork-Presbyterian / Columbia University Irving Medical Center
Patient Experience Rating
Current Combined Rating
The Patient Experience Star Rating represents how patients feel about the quality of their interaction with their Columbia provider during an office visit. This rating is derived from patient answers to four questions on a standardized experience survey, which is sent out to verified patients and administered by an independent third-party, Qualtrics. Responses are scored and converted to a scale from 1 to 5, with 5 being the highest rating.5.0 stars out of five. |129 ratings
- Did the provider explain things in a way that was easy to understand?
- Did the provider listen carefully to you?
- Did the provider treat you with courtesy and respect?
- How would you rate the provider on a scale from 0 to 10, with 10 being the best possible rating?
