Dr. Gomez-Simmonds' research interests entail understanding the clinical and molecular epidemiology of hospital-associated pathogens, particularly multidrug-resistant Gram-negative bacteria. She is currently working in Dr. Anne-Catrin Uhlemann's laboratory, where she has been focused on developing next-generation sequencing-based methods for investigating the repertoire of resistance gene and associated mobile genetic elements in these pathogens, with the goal of better understanding hospital-associated transmission of multidrug resistance. Other active areas of research include investigating the clinical, pathogen, and microbiome factors associated with colonization and subsequent infection with multidrug-resistant Gram-negative and other hospital-associated infections, such as Clostridioides difficile.